Remission of Parkinson's Disease Rest Tremor Following Cerebellar Hemorrhage

Authors

  • Leonor Rebordão Campus Neurológico, Torres Vedras, Portugal
  • Ângela Abreu Neurology Department, Hospital Nélio Mendonça. Funchal, Ilha da Madeira
  • João Peres Neurology Department, Hospital Prof. Doutor Fernando Fonseca, Amadora, Portugal
  • Joaquim J Ferreira Campus Neurológico, Torres Vedras, Portugal

Keywords:

Parkinson’s Disease, Rest Tremor, Cerebellar Hemorrhage

Abstract

Parkinson’s Disease (PD) is a clinical diagnosis that relies on the presence of bradykinesia and rigidity and/or rest tremor. Whereas the striatal dopamine depletion explains the characteristic PD symptoms such as bradykinesia and rigidity, the mechanism of tremor generation is not completely established. Mounting evidence suggests that resting tremor is associated with increased activity in a distinct cerebellothalamic circuit, which may explain its lower response to dopaminergic treatment.

We describe the case of a 74-year-old man with idiopathic tremor-dominant PD who experienced rest tremor remission after cerebellar hemorrhage, supporting the role of the cerebellum in rest tremor pathophysiology.

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Published

2025-06-30

Issue

Vol. 169 No. 2 (2025)

Section

Brief Report